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Association between body mass index and risk of total knee replacement, the Singapore Chinese Health Study

Identifieur interne : 003D65 ( Main/Exploration ); précédent : 003D64; suivant : 003D66

Association between body mass index and risk of total knee replacement, the Singapore Chinese Health Study

Auteurs : Ying-Ying Leung ; John Carson Allen ; Maria Noviani ; Li-Wei Ang [Singapour] ; Renwei Wang [États-Unis] ; Jian-Min Yuan [États-Unis] ; Woon-Puay Koh [Singapour]

Source :

Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society [ 1063-4584 ] ; 2014.

RBID : PMC:4275403

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Arthroplastie prothétique de genou (), Chine (ethnologie), Femelle, Gonarthrose (), Humains, Indice de gravité médicale, Indice de masse corporelle, Mâle, Risque, Singapour, Sujet âgé, Études prospectives.
MESH :
- ethnologie : Chine.
- Adulte d'âge moyen, Arthroplastie prothétique de genou, Femelle, Gonarthrose, Humains, Indice de gravité médicale, Indice de masse corporelle, Mâle, Risque, Singapour, Sujet âgé, Études prospectives.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Aged, Arthroplasty, Replacement, Knee (statistics & numerical data), Body Mass Index, China (ethnology), Female, Humans, Male, Middle Aged, Osteoarthritis, Knee (surgery), Prospective Studies, Risk, Severity of Illness Index, Singapore.
MESH :
- geographic , ethnology : China.
- statistics & numerical data : Arthroplasty, Replacement, Knee.
- surgery : Osteoarthritis, Knee.
- Aged, Body Mass Index, Female, Humans, Male, Middle Aged, Prospective Studies, Risk, Severity of Illness Index, Singapore.

Abstract

Purpose

Data on the association between body mass index (BMI) and risk of knee osteoarthritis (KOA) are sparse for Asian populations who are leaner than Western populations. We evaluated the association between BMI and risk of total knee replacement (TKR) due to severe KOA among Chinese in Singapore.

Methods

We used data from the Singapore Chinese Health Study, a population based prospective cohort of 63,257 Chinese men and women, aged 45–74 years at enrollment from 1993 to 1998. Information on height, weight, diet and lifestyle factors were obtained via in-person interviews. TKR cases for severe KOA were identified via linkage with the nationwide hospital discharge database through 2011. Cox regression and weighted least squares regression were used in the analysis.

Results

The mean BMI among cohort participants was 23.1 kg/m², and more than two-thirds had BMI below 25 kg/m². A total of 1,649 had TKR attributable to severe KOA. Risk of TKR increased in a strong dose-dependent manner with increasing BMI throughout the 15–32 kg/m² range and became less clear at BMI > 32 kg/m². In the BMI range 16–27 kg/m², there was a 27% increase in TKR risk for each unit increase in BMI (p for trend < 0.001). Compared to BMI 19–20 kg/m², the risk estimates of TKR were all statistically significant with increasing unit of BMI ≥ 21 kg/m². Results were similar for men and women.

Conclusion

Our results provided evidence for a constant mechanical mechanism underlying BMI and KOA initiation and/or progression.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275403

DOI: 10.1016/j.joca.2014.10.011
PubMed: 25450848
PubMed Central: 4275403

Affiliations:

Le document en format XML

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<term>Arthroplasty, Replacement, Knee (statistics & numerical data)</term>
<term>Body Mass Index</term>
<term>China (ethnology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Osteoarthritis, Knee (surgery)</term>
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<term>Chine (ethnologie)</term>
<term>Femelle</term>
<term>Gonarthrose ()</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Indice de masse corporelle</term>
<term>Mâle</term>
<term>Risque</term>
<term>Singapour</term>
<term>Sujet âgé</term>
<term>Études prospectives</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Osteoarthritis, Knee</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Body Mass Index</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Risk</term>
<term>Severity of Illness Index</term>
<term>Singapore</term>
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<term>Arthroplastie prothétique de genou</term>
<term>Femelle</term>
<term>Gonarthrose</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Indice de masse corporelle</term>
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<term>Risque</term>
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<term>Sujet âgé</term>
<term>Études prospectives</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P2">Data on the association between body mass index (BMI) and risk of knee osteoarthritis (KOA) are sparse for Asian populations who are leaner than Western populations. We evaluated the association between BMI and risk of total knee replacement (TKR) due to severe KOA among Chinese in Singapore.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P3">We used data from the Singapore Chinese Health Study, a population based prospective cohort of 63,257 Chinese men and women, aged 45–74 years at enrollment from 1993 to 1998. Information on height, weight, diet and lifestyle factors were obtained via in-person interviews. TKR cases for severe KOA were identified via linkage with the nationwide hospital discharge database through 2011. Cox regression and weighted least squares regression were used in the analysis.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">The mean BMI among cohort participants was 23.1 kg/m<sup>2</sup>
, and more than two-thirds had BMI below 25 kg/m<sup>2</sup>
. A total of 1,649 had TKR attributable to severe KOA. Risk of TKR increased in a strong dose-dependent manner with increasing BMI throughout the 15–32 kg/m<sup>2</sup>
 range and became less clear at BMI > 32 kg/m<sup>2</sup>
. In the BMI range 16–27 kg/m<sup>2</sup>
, there was a 27% increase in TKR risk for each unit increase in BMI (p for trend < 0.001). Compared to BMI 19–20 kg/m<sup>2</sup>
, the risk estimates of TKR were all statistically significant with increasing unit of BMI ≥ 21 kg/m<sup>2</sup>
. Results were similar for men and women.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P5">Our results provided evidence for a constant mechanical mechanism underlying BMI and KOA initiation and/or progression.</p>
</sec>
</div>
</front>
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Association between body mass index and risk of total knee replacement, the Singapore Chinese Health Study

Association between body mass index and risk of total knee replacement, the Singapore Chinese Health Study

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Descripteurs français

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Abstract

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